Table of Contents
International Journal of Brain Science
Volume 2014, Article ID 907581, 10 pages
Research Article

Prenatal Curcumin Administration Reverses Behavioral and Neurochemical Effects and Decreases iNOS and COX-2 Expressions in Ischemic Rat Pups

1Faculty of Medicine Estácio de Juazeiro do Norte (FMJ), Avenida Tenente Raimundo Rocha 515, Cidade Universitária, 63040-360 Juazeiro do Norte, CE, Brazil
2Faculty of Medicine of the Federal University of Ceará (UFC), Rua Cel. Nunes de Melo 1127, Rodolfo Teófilo, 60430-270 Fortaleza, CE, Brazil
3Faculty of Medicine of the Federal University of São Paulo (UNIFESP), Rua Pedro de Toledo 669, Vila Mariana, 04039-032 São Paulo, SP, Brazil

Received 24 August 2014; Revised 18 November 2014; Accepted 18 November 2014; Published 29 December 2014

Academic Editor: João Quevedo

Copyright © 2014 Maria Valéria Leimig Telles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objectives were to evaluate alterations in ischemic rat pups, from dams administered with curcumin (25 and 50 mg/kg). Ten-day-old male pups were subjected or not (SO) to brain ischemia and reperfusion, for 1, 7, and 14 days (this last group was submitted to behavioral evaluation). After that, pups were euthanized for determinations of striatal DA and DOPAC in SO, ischemic from untreated (ICUD) or curcumin treated (ICTD) dams, as well as hippocampal immunohistochemistry assays for iNOS and COX-2 and cresyl violet staining. At the 14th postischemia day, the ICUD group showed increased locomotor activity and rearing behavior, which were reversed in ICTD animals. ICUD pups presented decreased striatal DA and DOPAC levels, relatively to SO, mainly at the 1st postischemia day, but also at the 7th and 14th days which were partially reversed in ICTD pups. A greater number of viable neurons were observed in ICTD, as related to the ICUD group. Ischemia increased iNOS and COX-2 expressions, in CA1 and CA3 areas, at the 1st, 7th, and 14th postischemia days, and these effects were minimized in ICTD pups. In conclusion, the prenatal curcumin treatment was shown to be neuroprotective where the drug anti-inflammatory and antioxidant effects probably play a role.