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International Journal of Cell Biology
Volume 2009, Article ID 906507, 11 pages
Review Article

Cellular Therapy for Repair of Cardiac Damage after Acute Myocardial Infarction

1Adult Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, QLD 4101, Australia
2School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia

Received 11 December 2008; Accepted 3 February 2009

Academic Editor: Gary S. Stein

Copyright © 2009 Matthew M. Cook et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular diseases, particularly acute myocardial infarction, are the leading causes of death worldwide. Important advances have been made in the secondary treatment for cardiovascular diseases such as heart transplantation and medical and surgical therapies. Although these therapies alleviate symptoms, and may even improve survival, none can reverse the disease process and directly repair the lasting damage. Thus, the cure of cardiovascular diseases remains a major unmet medical need. Recently, cellular therapy has been proposed as a candidate treatment for this. Many stem and progenitor cell populations have each been suggested as a potential basis for such therapy. This review assesses some of the more notable exogenous adult cell candidates and provides insights into the mechanisms by which they may mediate improvement in cardiac function following acute myocardial infarction. Research into the cellular therapy field is of great importance for the further planning of clinical trials for cardiac cellular myoplasty.