Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
Altered caspase processing in caspase-9, -2, or -3 deficient MEFs upon exposure to ER stress. Indicated wild-type and caspase deficient MEFs were treated with thapsigargin (2 M) for 12, 24, 36, and 48 hours. Protein extracts were isolated and subjected to western blot analysis using the indicated antibodies. Staurosporine (Sts) 100 nM for 12 hours was used as a positive control for caspase processing. Images are representative of a least 2 independent experiments.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.