Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery

Figure 1

Cartoon illustrating acetylation and deacetylation at the ε-amino group of a lysine residue. A KAT is responsible for transfer of an acetyl moiety (in yellow) from acetyl-CoA to the ε-group of a lysine residue, whereas an HDAC removes the acetyl group from acetyl lysine, releasing acetate. Note that sirtuins use a catalytic mechanism that is completely different from what is illustrated here for the Rpd3/Hda1 family of deacetylases.