International Journal of Cell Biology / 2010 / Article / Fig 6

Research Article

The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration

Figure 6

Differential stress responses of neurons and astrocytes. Neurons (7 div) and astrocytes were subjected to heat shock (HS; 44°C, 30 minutes) or oxidative stress (OS; 100  M H2O2) and cell lysates were prepared after a recovery period of 24 hours and equal amounts of proteins were subjected to immunoblot analysis, using antibodies against a variety of heat shock proteins, as indicated on the right. Note that in both neurons and astrocytes, HSP70 is heat-inducible, while HSP32 is only induced by oxidative stress. Generally, the induction of HSPs after stress is more pronounced in astrocytes than in neurons.

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