Band 3 Missense Mutations and Stomatocytosis: Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak
Figure 3
Putative transport states of AE1. Whereas the wt AE1 does only exchange Clā and , a A mutated state only conducts monovalent cations and a B mutated state shows both transport activities, anion exchange and cation leak. The A state should be obtained with L687P, D705Y, R730C, S731P, H734R, S762R and G796R mutations. The B state should be obtained with E758K and R760Q mutations.
