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International Journal of Cell Biology
Volume 2011, Article ID 246954, 14 pages
Review Article

Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR

1Bordeaux Cardiothoracic Research Center, Bordeaux University, 146, Léo-Saignat, 33076 Bordeaux, France
2Inserm U1045, 146, Léo-Saignat, 33076 Bordeaux, France

Received 28 January 2011; Accepted 1 April 2011

Academic Editor: Michael Hortsch

Copyright © 2011 Frederic Delom and Delphine Fessart. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle.