PAI-1: An Integrator of Cell Signaling and Migration

Figure 2

Integration of PAI-1 into cellular motile/proliferative pathways. Clustergram analysis of microarray data positions PAI-1 as a hub element both as a target and initiator (or inhibitor) of various pathways that regulate cellular motile (e.g., uPA, TGF-β1), proliferative (e.g., ETS, MYC, AKT), and survival/stress (e.g., JNK, caspase, NFκB, TNFR) programs.