International Journal of Cell Biology / 2012 / Article / Tab 5

Review Article

Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer

Table 5

Studies on plastins in cancer cells.

Key words of the studyReferences

Ectopic expression of L-plastin in cancer
 Transformed human fibroblasts[11]
 Many types of human cancer[54]
 L-plastin gene promoter in cancer[5557]
 Ovarian steroid hormones[58]
 Prostate cancer and steroid hormone[59]
 Chromosome translocation[60]
 Breast cancer and expression pattern[61]
 Colorectal cancer and metastasis[62]
 Colon cancer, invasion, and loss of E-cadherin[63]
 Melanoma tumor invasion[64]
 T-plastin downregulation and CpG methylation[65]
Ectopic expression of T-plastin in lymphoma
 Cutaneous T cell lymphoma[66, 67]
 Sezary cells[68, 69]
As a biomarker for cancer screening and diagnosis
 Choroid plexus tumors and diagnostic marker[71]
 Bladder cancer and biomarker[72]
 Proteomics imaging and mass spectrometry[73]
 Colorectal cancer and human feces[74]
Gene therapies targeting L-plastin gene
 L-plastin promoter and gene therapy[7577]
 Antisense L-plastin gene and tumor suppression[78]

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