Turnover of Focal Adhesions and Cancer Cell Migration

Figure 5

A model for the recruitment of disassembly factors to FAs. In this model, ZF21 conveys FA disassembly factors via intracellular vesicle transport on MTs. ZF21 associates with endosomal vesicles by binding to phosphatidylinositol-(3)-phosphate via its FYVE domain. m-Calpain and SHP-2 can be loaded onto ZF21 carried by the vesicles. ZF21 also can be found in FAs by interacting with FAK, and the ability of ZF21 to bind β-tubulin may act as a docking function for the extended MTs into FAs in order to unload the conveyed factors at the destination.