Reactive Oxygen Species-Mediated Control of Mitochondrial Biogenesis

Figure 2

The Saccharomyces cerevisiae oxidative phosphorylations (OXPHOS) system. The main differences with the mammalian OXPHOS system are the absence of complex I that is substituted by external and internal NADH dehydrogenases, and the presence of D, L-lactate dehydrogenases, which transfer electrons directly to cytochrome c. Indicated are the number of protein subunits encoded by mitochondrial (mtDNA) and nuclear (nDNA) genomes.