Review Article

Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures: Functional Implications in Epilepsy

Figure 4

Comparison of immunohistochemical labeling for acidic calponin in hippocampal formation from control (Ctl; a) and pilocarpine-treated animals at 1 week (b), 2 weeks (c), and 16 weeks (d). In a Ctl rat (a), immunolabeling for acidic calponin in the dentate gyrus (DG) is mainly found in astrocytes (arrows) and cells located along the infragranular region of the granule cell layer (G). A diffuse staining is evenly observed in all parts of the molecular layer (M) including the inner molecular layer (IML). In pilocarpine-treated animals at 1 and 2 weeks, immunolabeling for acidic calponin is substantially increased in IML of the DG compared with Ctl (a) and to pilocarpine-treated rats at 16 weeks (d). In all pilocarpine-treated animals, immunolabeling for acidic calponin is also found in astrocytes (see arrows) located in the M. Scale bars = 50 μm in (a), (b), (c), and (d). (e) Table showing the comparison of % optical density for acidic calponin protein in G and IML between Ctl and pilocarpine-treated animals at 1, 2, and 16 weeks. G: granule cell layer; IML: inner molecular layer; P: probability; NS: not significant. Modified with permission from [58].
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