Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures: Functional Implications in Epilepsy

Figure 6

Scheme illustrating the potential role of drebrin A in reactive synaptic plasticity after pilocarpine-induced seizures. Drebrin A together with other proteins such as synaptopodin might be more involved in the structural integrity and stabilization of dendritic spines of hippocampal granule cells, and glutamatergic synaptic function that underlies the development of spontaneous recurrent seizures in pilocarpine animals, at chronic stage, whereas acidic calponin could contribute to the plastic changes in shape and density occurring after status epilepticus.