Review Article

Pexophagy: The Selective Degradation of Peroxisomes

Figure 7

Hypothetical mechanistic model of pexophagy in mammalian cells. Processed and lipidated LC3 (LC3-II) is integrated into the expanding phagophore membrane (PM) and also may be involved in facilitating directed movement of the PM structure by interacting with microtubules (MT) via the RAB7 effector FYCO1 and motor protein Kinesin. Targeting of peroxisomes may either be accomplished by p62-mediated detection of ubiquitin (UB) motifs on still unknown peroxisomal membrane (or membrane associated) proteins (X) or by direct binding of LC3 to PEX14, a process which is discussed to compete with the binding of PEX5 to PEX14 (dotted arrow). See text for details.
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