The roles of Rab GTPases involved in integrin trafficking. Integrins can be internalized by a clathrin-dependent, caveolin-dependent, or clathrin- and caveolin-independent pathway. For example, some integrins are internalized by a Rab21 and clathrin-independent pathway. Once internalized, integrins can be recycled back to the plasma membrane by a Rab4-dependent manner or can be transported to the perinuclear recycling compartment. Rab11 family members (Rab11 and Rab25) regulate recycling of integrins from perinuclear recycling compartment.
