Integrin Trafficking and Tumor Progression

Table 1

Mechanisms of the internalization and recycling of integrins α5β1, α6β4, αvβ3, and αvβ6.

Integrin	Internalization		Recycling
	Associated proteins	Comments	Associated proteins	comments
α5β1	Numb	Clathrin-dependent	Rab11	Akt/GSK-3β-dependent
	AP2 associated with tetraspanin	Clathrin-dependent	Rab11 RCP	Akt-dependent
	NRP1	Clathrin-dependent	VAMP3	SNARE-mediated
	Rab21	Clathrin-dependent	Rab21	Required for cytokinesis
	?	Caveolin-dependent	Rab25	Promote invasion in 3D
α6β4			Rab11	Akt/GSK-3β-dependent
αvβ3	Numb; ?	Clathrin-dependent; Caveolin-dependent	Rab4, PKD1; Rab4, RABIP4; Rab11	PDGF- or VEGF-driven; PDGF-driven; Akt/GSK-3-dependent
αvβ6	HAX1	Clathrin-dependent