TY - JOUR A2 - Filomeni, Giuseppe AU - Banerji, Versha AU - Gibson, Spencer B. PY - 2012 DA - 2012/07/08 TI - Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies SP - 595976 VL - 2012 AB - Autophagy is a cellular process that maintains the homeostasis of the normal cell. It not only allows for cell survival in times of metabolic stress with nutrient recycling but also is able to lead to cell death when required. During malignant transformation the cell is able to proliferate and survive. This is due to altered cell metabolism and the presence of altered genetic changes that maintain the cell survival. Metabolism was considered an innocent bystander that was a consequence of the increased nutrient requirement for the survival and proliferation of haematological malignancies. The interdependency of metabolism and cellular mechanisms such as autophagy are becoming more evident and important. This interdependence contributes to increased cancer progression and drug resistance. In this paper we aim to discuss autophagy, how it pertains to metabolism in the context of hematologic malignancies, and the implications for therapy. SN - 1687-8876 UR - https://doi.org/10.1155/2012/595976 DO - 10.1155/2012/595976 JF - International Journal of Cell Biology PB - Hindawi Publishing Corporation KW - ER -