Transmission Electron Microscopy Studies of Cellular Responses to Entry of Virions: One Kind of Natural Nanobiomaterial
Figure 2
Severe acute respiratory syndrome-associated coronavirus (SARS CoV) in Vero E6 cell. (a) The virions attached themselves to the cell surface (arrow), and then their envelopes fused with cell membrane and the nucleocapsids entered the cell. The contours of these nucleocapsids were blurry after the virions lost their envelopes (arrowhead). (b) Nucleocapsids assembled in the swollen RER (arrow). Some ribosomes attached on the membrane of the RER. (c) Release of the virions from the cell. A smooth vesicle was fusing with the cell membrane (wide arrow); virions still located in the smooth vesicles (sharp arrow). (d) Budding of the nucleocapsids from the VMMV to the smooth vesicles. The SARS CoV nucleocapsids budded from the VMMV (sharp arrow) into the smooth vesicles and obtained spikes and envelopes (wide arrow). nm [12].
