Review Article

Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation

Table 1

Expression level of cell adhesion-relating molecules (VLA-4, 5, and syndecan-4) and induced cell adhesion or apoptosis by TNIIIA2 or Mg2+ administration in fresh AML cells from patients, peripheral blood cells from healthy adults, and hematopoietic tumor cell lines (the table was modified from [19]).

Cells     Expression (%)AdhesionApoptosis
VLA-4VLA-5Syndecan-4+TNIIIA2+Mg2++TNIIIA2+Mg2+

“Fresh AML cells”
 Patient A98.288.848.8+++++++
 Patient B97.598.59.5+++
“Peripheral blood cells”
 Neutrophil6.7N.D.3.2
 Monocyte48.6N.D.2.0++++
 Lymphocyte40.5N.D.4.4+++
“Cell lines”
 B cell
  Ramos96.53.292.1++++++++++
  Raji94.365.32.3++++
 T cell
  Jurkat92.896.642.4++++++++++
 Erythroid
  K5629.397.266.7+++++
 Myeloid
  U93798.198.287.5++++++++++
  HL6099.899.775.3++++++++
  THP168.520.730.1+++++++
  THP1 (+PMA)10.518.799.2++++

Expression of VLA-4, 5 and syndecan-4 was evaluated by flowcytometric analysis.