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International Journal of Cell Biology
Volume 2012 (2012), Article ID 651805, 9 pages
Review Article

Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases

1Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, Italy
2National Institute for Infectious Diseases IRCCS “L. Spallanzani”, Via Portuense, 00149 Rome, Italy

Received 8 February 2012; Accepted 18 March 2012

Academic Editor: Pier Giorgio Mastroberardino

Copyright © 2012 Federica Di Sano and Mauro Piacentini. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.