International Journal of Cell Biology / 2012 / Article / Tab 1

Review Article

Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion

Table 1

Prostaglandins in cancer cell adhesion, migration, and invasion summary table.

Adhesive factorTissuePGBiological effectRefs

Cadherins
E-cadherinRIE-S↑PGE2COX-2-mediated PGE2 production in rat intestinal epithelial cells (RIE) downregulates E-cadherin[88]
E-cadherinSCC↑PGE2Downregulates E-cadherin through the EP2 receptor during squamous cell carcinoma (SCC) progression [53]
↑E-cadherinNSCLCPGE2S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1 [84]
E-cadherinTCC↑PGE2Reciprocal correlation between cyclooxygenase-2 expression and E-cadherin in human bladder transitional cell carcinoma (TCC). [85, 87]
↑E-cadherinMelanoma↑PGE2Decrease of TGFβ1-induced EMT properties in Madin-Darby canine kidney (MDCK) cells is associated with regaining E-cadherin expression [257]
↑E-cadherinMDCK↑PGD2Decrease of TGFβ1-induced EMT properties in MDCK cells is associated with regaining E-cadherin expression [258]
VE-cadherinHLVEPGI2Inhibition of PGI2-mediated human lung vascular endothelial cell (HLVE) responses decreased VE-cadherin expression and increased eosinophil adhesion[259]

Focal adhesions
↑Actin bundlesHeLa↑PGE2Examination of cyclooxygenase-dependent actin bundles in HeLa cells. [144]
CREB activationRaw264.7↑COX2Examination of Col-I on the COX-2 expression and the signaling pathways in macrophages. [145]
↑Focal adhesionsOsteoblasts↑COX2Focal adhesion promotes fluid shear stress induction of COX-2 and PGE2 release in osteoblasts [146148]
↑Focal adhesions293-EBNA-HEK↑PGF2αRegulates Rho-mediated morphological changes [150, 151]

Integrins
Caco-2↑LTD4/↑PGE2Increased adhesion to collagen I. [177]
HT-29PGE2Decreased adhesion and migration on extracellular matrix [178]
Mammary TCPGE2Decreased adhesion to laminin[179]
HLC↑PGE2Increased adhesion of human lung carcinoma (HLC) cells to fibronectin [180]
αIIb B16a melanoma↑12-HETEIncreased adhesion to fibronectin, endothelial cells, and endothelial cell matrix [182, 183]

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