Research Article

Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced -Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Figure 6

System characteristics under KGDHC inhibition. ATP production rate (red), NADH level (green), mitochondrial membrane potential (magenta, right scale), and reduced cytochrome c level (black) at normal ATP demand versus increased inhibition of KGDHC, maximal ATP production capacity in blue. Values except membrane potential normalized to reference state without inhibition.
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