The Role of Lipid Rafts in Cancer Cell Adhesion and Migration
Figure 1
Cholesterol lowering stimulates CD44 shedding and suppresses cancer cell migration. (a) Modulation of cellular cholesterol affects CD44 shedding from human glioma cells. Cells were cholesterol-depleted (MβCD), cholesterol-replenished (MβCD/Chol), or left untreated (control), and CD44 shedding was assessed by measurement of soluble CD44 in the culture medium. (b) Effect of simvastatin on CD44 shedding. Cells were incubated in the presence or absence of simvastatin, and CD44 shedding was assessed by measurement of soluble CD44 in the culture medium. (c) Effect of simvastatin on CD44-dependent cell migration. Cells were incubated in the presence or absence of simvastatin, and treated with hyaluronan oligosaccharides (o-HA) or EGF.
