The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function

Figure 1

Schematic of the structure of LPL. The N-terminal “headpiece” contains at least one serine phosphorylation site (arrow; serine residue 5) and EF hand loops (labeled “EF”) that are thought to participate in the calcium regulation of LPL. The C-terminal portion contains two tandem ABDs, each of which consists of two calponin-homology (CH) domains, which are numbered.