Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases

Table 1

Ideal properties for a diagnostic small molecule.

(i) Stable in vivo
(ii) Moderately lipophilic
(iii) Entering the brain in sufficient amounts and retained in the brain
(iv) Low uptake of metabolites to brain
(v) Detection of plaques (imaging properties)
(vi) High specificity for amyloid deposits, low nonspecific bonding