RNA Splicing: A New Player in the DNA Damage Response

Figure 1

How the DDR can affect alternative splicing. The activation of the DDR can modify alternative splicing by affecting the expression, or by inducing posttranslational modifications of splicing factors (SFs), that may alter their intracellular localization and/or their activity. Moreover, also the elongation activity of RNA polymerase II (RNAPII) can be influenced by genotoxic stress, modifying in turn pre-mRNA splicing.