TY - JOUR
A2 - Inaba, Kenji
AU - Ramming, Thomas
AU - Appenzeller-Herzog, Christian
PY - 2013
DA - 2013/10/24
TI - Destroy and Exploit: Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum
SP - 180906
VL - 2013
AB - Peroxidases are enzymes that reduce hydroperoxide substrates. In many cases, hydroperoxide reduction is coupled to the formation of a disulfide bond, which is transferred onto specific acceptor molecules, the so-called reducing substrates. As such, peroxidases control the spatiotemporal distribution of diffusible second messengers such as hydrogen peroxide (H2O2) and generate new disulfides. Members of two families of peroxidases, peroxiredoxins (Prxs) and glutathione peroxidases (GPxs), reside in different subcellular compartments or are secreted from cells. This review discusses the properties and physiological roles of PrxIV, GPx7, and GPx8 in the endoplasmic reticulum (ER) of higher eukaryotic cells where H2O2 and—possibly—lipid hydroperoxides are regularly produced. Different peroxide sources and reducing substrates for ER peroxidases are critically evaluated. Peroxidase-catalyzed detoxification of hydroperoxides coupled to the productive use of disulfides, for instance, in the ER-associated process of oxidative protein folding, appears to emerge as a common theme. Nonetheless, in vitro and in vivo studies have demonstrated that individual peroxidases serve specific, nonoverlapping roles in ER physiology.
SN - 1687-8876
UR - https://doi.org/10.1155/2013/180906
DO - 10.1155/2013/180906
JF - International Journal of Cell Biology
PB - Hindawi Publishing Corporation
KW -
ER -