Destroy and Exploit: Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum
Figure 3
Superimposition of GPx7 and GPx8. Overlay of the carbon-nitrogen backbones of GPx7 (green; PDB ID 2KIJ) and GPx8 (red; PDB ID 2P31) was done using the Swiss PDB viewer software (available at http://www.expasy.org/). The close resemblance of the two three-dimensional structures is particularly appreciable in the peptide loops surrounding the active site Cys (CP). The ESP retention signal (KEDL motif) and the location of the transmembrane domain (TMD) of GPx8 (not part of the crystal structure) are indicated.
