Destroy and Exploit: Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum
Figure 5
The two-disulfides-out-of-one-O2 concept. O2 (red)-mediated oxidation of Ero1α results in the generation of one disulfide bond (red), which is transferred to a reduced PDI, and of one molecule of H2O2. ER-resident peroxidases (P)—probably exclusively of the GPx family (see main text for details)—can couple the reduction of Ero1α-derived H2O2 to H2O with the introduction of a second disulfide bond (red) into a PDI family member, thereby exploiting the oxidizing capacity of H2O2.
