Destroy and Exploit: Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum

Table 1

Published peroxide and reducing substrates of ER-resident peroxidases.

	Peroxide substrates	Reducing substrates
PrxIV	H2O2 [76]	PDIs (ERp46, P5, PDI) [75, 83]
GPx7	H2O2 [88]; phospholipid hydroperoxide [86]	PDIs (PDI, ERp46, ERp57, ERp72, P5); [86, 88, 89], GRP78/BiP [90], GSH [86], XRN2 [93]
GPx8	H2O2 [88]	PDIs (PDI, ERp46, ERp57, ERp72, P5) [88]