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International Journal of Cell Biology
Volume 2013, Article ID 243876, 14 pages
Research Article

Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death

1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
2SysBio Centre of Systems Biology, Piazza della Scienza 2, 20126 Milan, Italy

Received 2 December 2012; Revised 22 February 2013; Accepted 28 February 2013

Academic Editor: Claudia Cerella

Copyright © 2013 Roberta Palorini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Representative profiles of PI/Annexin V staining for MDA-MB-231 cells treated with rotenone and FSK alone or in combination.

The profiles, together with the quantitative analysis (figure 3C), indicate that FSK treatment of MDA-MB-231 cells enhances the viability loss induced by rotenone alone.

  1. Supplementary Figures