Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations
Figure 5
Neurotoxicity of extracellular 15.5 nM monomeric, dimeric, and trimeric forms of 1N4R and 2N4R tau variants toward (a) nondifferentiated human neuroblastoma cells (SH-SY5Y) and (b) Retinoic-acid-differentiated SH-SY5Y cells was measured after 48-hour incubation using an LDH assay. For both four-repeat tau isoforms, trimeric form is more neurotoxic than monomeric and dimeric forms () on either neuron type. Full-length trimeric rhTau is more neurotoxic than 1N4R trimeric rhTau. ().
