Disulfide Bonding in Neurodegenerative Misfolding Diseases

Mossuto, Maria Francesca

doi:https://doi.org/10.1155/2013/318319

International Journal of Cell Biology

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Special Issue

Protein Misfolding and Neurodegenerative Diseases

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Review Article | Open Access

Volume 2013 | Article ID 318319 | https://doi.org/10.1155/2013/318319

Disulfide Bonding in Neurodegenerative Misfolding Diseases

Maria Francesca Mossuto¹

Academic Editor: Roberto Chiesa

Received17 May 2013

Accepted16 Jul 2013

Published01 Aug 2013

Abstract

In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell. Of all the factors that affect the behavior of these proteins, disulfide bonds are likely to be important, being very conserved in protein sequences and being the enzymes devoted to their formation among the most conserved machineries in mammals. Their crucial role in the folding and in the function of a big fraction of the human proteome is well established. The role of disulfide bonding in preventing and managing protein misfolding and aggregation is currently under investigation. New insights into their involvement in neurodegenerative diseases, their effect on the process of protein misfolding and aggregation, and into the role of the cellular machineries devoted to disulfide bond formation in neurodegenerative diseases are emerging. These studies mark a step forward in the comprehension of the biological base of neurodegenerative disorders and highlight the numerous questions that still remain open.

1. Introduction

Neurodegenerative misfolding diseases (NMD) are a group of diseases involving the misfolding of one or two proteins and their accumulation into aggregated species toxic to neurons, leading to a wide range of neurological symptoms (Table 1). Among these are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), prion-related disorders (PrDs), and amyotrophic lateral sclerosis (ALS). In each case a specific protein loses its functional structure to populate partially unfolded species that reorganize themselves into polymeric structures with different degrees of ordered structure, from oligomers to amyloid fibrils [1].

The fate of a protein depends on two major factors, its sequence and its cellular environment. From the sequence perspective, many studies have identified several features of the amino acid sequence of a protein that help predict its aggregation behavior, such as charge, hydrophobicity, patterns of polar and nonpolar residues, and tendency to form secondary structures [2, 3]. After peptide bond, the disulfide bond is the most common covalent link between amino acids in proteins. Disulfide bonds are known to stabilize proteins thermodynamically by decreasing the entropy of the unfolded state, to increase mechanical stability and to confine conformational changes [4]. From the cellular environment point of view, instead, in order to be formed, disulfide bonds need a highly efficient network of enzymes in particular cellular compartments, such as protein disulfide isomerases (PDIs), whose role has been revealed as central in many neurodegenerative disorders, being upregulated in many NMD and in some cases interacting directly with misfolded and aggregated proteins [5, 6].

Disulfide bonds are present in 15% of the human proteome and they are enriched in secreted proteins (65%), due to the need of greater protein stability in the absence of the accurate quality control systems present inside the cell. Interestingly they are present in 55% of the proteins involved in pathologic amyloid formation [7], suggesting an important role of disulfide bonds in the kinetics of aggregation and in the structure and toxicity of the formed aggregates. Do disulfide bonds have a role in neurodegenerative misfolding disorders? The analysis of a list of proteins that misfold and aggregate in neurodegenerative diseases (Table 1) revealed that only 25% of the proteins listed have disulfide bonds, a value closer to the general presence of disulfide bonds in the proteome (15%).

This distribution of disulfide bonds presence in proteins involved in misfolding diseases (Figure 1) shows that while proteins without disulfide bonds mainly aggregate in and impair neurons, proteins with disulfide bonds are mostly involved in systemic pathologies. Do neurons produce less disulfide-bonded proteins? Are neurons more sensitive to intracellular aggregates formed by cytosolic proteins (mostly disulfide free) or to the stress caused by their presence? Interestingly, a well-known cytosolic and neurotoxic protein (huntingtin fragment with extended polyglutamine repeat) has been expressed in the endoplasmic reticulum, and surprisingly it did not form aggregates [8]. The authors suggest that polyglutamine aggregation is a property restricted to the nucleocytosolic compartment and that compartment-specific cofactors promoting or preventing the aggregation of pathological proteins could exist. Is there any difference in the aggregation and cytotoxic behavior of cytosolic and secreted proteins?

The questions about protein aggregation, disulfide bonds, and neurotoxicity are numerous, and the proposed answers are often controversial. Here we focus on two simple aspects of disulfide bonds and neurodegenerative diseases: the role of disulfide bonds in the stabilization of proteins involved in aggregation and neurodegeneration and the involvement of PDIs in neurodegenerative misfolding diseases.

2. Disulfide Bonds in Proteins Aggregated in Neurodegenerative Diseases

Proteins have evolved several structural and sequence-based strategies to avoid misfolding and potentially toxic aggregation such as stabilizing protein folding, controlling aggregation by gatekeepers residues, limiting β-propensity, hydrophobicity, and net charge [9].

Many studies on the effects of disulfide bonds on protein misfolding and aggregation revealed that (i) some disulfide bonds are positioned to prevent the population of aggregation prone conformation of some proteins (insulin, IAPP, β-lactoglobulin, and lysozyme) [3, 7, 10], (ii) disulfide may promote specificity in intermolecular association occurring by domain swapping [11], (iii) considering large protein structure datasets, regions of proteins involved in protein-protein interactions, and therefore often aggregation prone, was observed to be enriched in disulfide bonds [12], and (iv) in the human proteome, disulfide bonds are associated with sequences (both intra- and extracellular) of higher aggregation propensity [7]. These observations suggest that disulfide bonds have coevolved with protein sequences to minimize protein misfolding and propensity to form potentially toxic aggregates.

The involvement of disulfide bonds in proteins involved in neurodegenerative misfolding diseases is limited to the few proteins that have them, that is, prion, SOD1, and Tau. Nonetheless, the study of the role of disulfide bonds in protein stability and in the aggregation process has not led to a definitive scenario. Here, an overview of the open questions about the involvement of disulfide bonds in each one of the tree proteins involved in NMD is presented.

2.1. Prions

Prion-related disorders are neurodegenerative diseases characterized by the conversion of the prion protein PrP from its normal cellular structure to a highly β-sheet, protease-resistant, scrapie conformation . The only PrP disulfide bond (Cys179–Cys214) stabilizes the overall fold of the protein by connecting the two long C-terminal helices [13]. Whether the presence of the intact disulfide bond is required or not [14, 15] for aggregation, whether disulfide reshuffling occurs during to conversion in vivo, and whether intermolecular disulfide bonds play a role in stabilizing aggregates [16] are still subject of some controversy [17].

2.2. SOD1

Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. The cause of ALS is unknown although 5–10% of cases are familial with a Mendelian pattern of inheritance [18]. About 20% of familial ALS cases share a mutation in the copper/zinc superoxide dismutase 1 (SOD1) gene [19]. SOD1 is a powerful antioxidant protein that metabolizes oxygen radicals that are produced by cellular metabolism. The active enzyme is a homodimer: each subunit contains four Cys residues at positions 6, 57, 111, and 146. An intramolecular disulfide bond between cysteine residues 57 and 146 is required for folding and stabilization of mature SOD1 [20]. Many familial ALS mutations render SOD1 more sensitive to intramolecular disulfide bond reduction [21], decreasing the apparent melting point below physiological temperature [22] and a corresponding increase in the population of their (A4V, L38V, G93A, L106V) unfolded states [23].

Intermolecular disulfide bonds have been identified in SOD1 aggregates in animal models of familial ALS [24, 25]. Experimental evidence suggested that even if disulfide cross-linking is not required for aggregation of mutant SOD1 [26], disulfide scrambling by intra- and intermolecular isomerization constitutes an important pathway for the aggregation of mutant SOD1 [27].

Despite the importance of disulfide bonds in SOD1 and ALS, it is not known how the intramolecular disulfide bond is formed in the reducing environment of the cytosol and how the thiol-disulfide status of SOD1 changes in the course of the disease.

2.3. Tau

Tauopathies are a group of neurodegenerative diseases, including AD, Pick disease, and corticobasal degeneration, characterized by the accumulation of insoluble Tau fibrils. Tau exists as six different isoforms that result from alternative splicing of mRNA [28], and the longest isoform of Tau has two Cys residues at positions 291 and 322 (numbering based upon the longest form) that can form both intra- and intermolecular disulfide bonds. Although several studies suggest that intermolecular disulfide bonds can promote Tau aggregation in vitro, there are lines of evidence that intramolecular disulfide bonds retard Tau aggregation in vitro [29]. The precise mechanisms underlying these observations remain unclear. Recent data suggest that intra- and intermolecular disulfide bonds could be one of the factors determining the range of pathological Tau isoforms [30].

2.4. Use of Disulfide Engineering in Aβ

In many cases a disulfide bond has been added to proteins that misfold and aggregate in neurodegenerative disorders. The most studied case is Aβ, where disulfide bonds have been engineered to allow the homogeneous population and stabilization of specific aggregated species (hairpin conformations, dimers, oligomers, and fibrils) and the subsequent characterization of their biochemical, structural, and biological properties [31].

3. Disulfide Bonding in Neurodegenerative Misfolding Diseases

In eukaryotic organisms enzyme-catalyzed disulfide bonds are formed in specialized cell compartments, such as the endoplasmic reticulum (ER) and the intermembrane space of the mitochondria [32].

The ER not only provides an environment suitable for disulfide formation, being very oxidizing with a low GSH : GSSH ratio, but it contains also many proteins dedicated to protein folding and correct disulfide bonding. Already during their translocation into the ER lumen, proteins are oxidized by protein disulfide isomerases (PDIs). The PDIs are maintained in an oxidized state by the flavoprotein Ero1, which transfers electrons directly onto oxygen generating H₂O₂ [33].

PDI was the first enzyme characterized to catalyze thiol-disulfide exchange reactions in the ER, but in recent years the number of PDI family members has been growing very quickly [34]. In humans the PDI family currently has 20 defined family members, such as ERp57, ERp72, P5, ERp44, PDIp, ERp29, ERp19, and ERdj5, defined by similarity to PDI and localization in the ER. They all contain at least one domain that is similar to one of the four thioredoxin domains of PDI, but a detailed characterization of their specific physiological function has not yet been performed.

PDIs are a class of proteins activated upon ER stress [35]. Since extensive protein misfolding and aggregation have been found to induce massive ER stress, the involvement of PDIs in neurodegenerative misfolding diseases has been the subject of intensive studies. PDI family members have been reported to be upregulated in many mouse models of protein misfolding diseases and in postmortem human samples from patients affected with neurodegenerative diseases [5, 6]. Particular attention has been given to the role of PDIs to the pathogenesis of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), prion-related disorders (PrDs), and amyotrophic lateral sclerosis (ALS). In some cases, moreover, PDIs have been also shown to directly interact with misfolded or aggregated proteins [36–39]. The results have been extensively described in recent reviews [5, 6, 40]. Here the major findings are reported and classified for pathology, to highlight which are the common features and the unclear aspects.

3.1. Prion-Related Disorders

Creutzfeldt-Jacob (CJD) disease was the first human brain disease shown to be associated with an upregulation of PDIs, both by a proteomic study of sporadic CJD brain tissue [41] and by the analysis of several human brain samples from patients affected with sCJD and vCJD [42]. In particular ERp57 levels correlate with the levels of prions misfolding and inversely correlate with the extent of neuronal damage in murine models of infectious scrapie prions [38, 43] suggesting that ERp57 prevents aggregation and neurotoxicity of prion protein [38].

Moreover, PDI can physically interact with misfolded prion [38, 39], and general inhibition of PDI activity with bacitracin causes the increase of aggregated prion species [39], consistently with the idea that intermolecular disulfide bond formation is also an important factor in prion misfolding [16].

3.2. Amyotrophic Lateral Sclerosis (ALS)

Many studies report a link between PDI and the pathogenesis of ALS. PDI and ERp57 were identified as the two main proteins upregulated in the spinal cord of a symptomatic ALS transgenic mice [44], and in the spinal cord and CSF of human sporadic ALS patients [45, 46] where PDI also colocalizes with abnormal protein inclusions associated with sporadic ALS [47]. Interestingly, PDI colocalizes with inclusions in motor neurons of mutated SOD1 (G93A) mice [44] and in human ALS patients [45]. The finding that PDI overexpression in cell culture protects against mutant SOD1 neurotoxicity [48] further indicates that PDI has an important role in protection against mutant protein aggregation in ALS. Knocking down PDI increased the levels of mutant SOD1 aggregation, and its overexpression had the opposite effect [48]. Moreover, a small molecule mimicking the active site of PDIs decreases mutant SOD1 aggregation in vitro [48].

Besides physically interacting with SOD1 [44], moreover, PDI interacts also with FUS [49] and colocalizes with TDP43 in human ALS tissue [47].

Despite its demonstrated protective role, increased levels of PDI in ALS were not beneficial in patients. As previously shown for Parkinson’s and Alzheimer’s brain tissues [50], posttranslational modification of PDI by S-nitrosylation of the critical active site cysteine residues, leading to the inhibition of PDI enzymatic activity, has been observed also in spinal cord tissues of sporadic ALS patients and in transgenic SOD1G93A mice. PDI was found enriched and nitrated in the aggregates isolated from the spinal cord of an ALS mouse model [36, 51]. These modifications could explain the loss of protection by PDI in disease [48].

3.3. Parkinson’s Disease (PD)

Increased expression of PDIs family members has been observed in many studies on PD. PDI and ERp57 were found to be upregulated in two gene profile studies of PD cell culture models [52, 53]. PDIp is induced in a toxicological mouse model of PD and in brain tissue derived from PD patients [54]. PDI is overexpressed in α-synuclein transgenic mice [55]. The function of PDIs in PD in vivo, however, is still not clear.

PDI decreases the aggregation of the Parkinson’s disease-associated synphilin-1 protein in neuroblastoma cells [50]. It also prevents the aggregation of α-synuclein in cell-free in vitro systems [56].

3.4. Alzheimer’s Disease (AD)

PDI levels are increased in the brain of AD patients, where PDI colocalizes with neurofibrillary tangles in cells containing neurofibrillary tangles [57, 58]. ERp57 is found in the cerebrospinal fluid of AD patients physically associated with Aβ [37], suggesting a role as a carrier protein that prevents the aggregation of the Aβ peptide.

4. Conclusions

Protein sequences have used different strategies to evolve and reach their functional folding in an efficient way, minimizing the risks of misfolding and (toxic) aggregation [9]. Disulfide bonds carry out this job by a double action: on one side, due to their covalent nature, they stabilize protein structure and functionality, on the other side a family of proteins (PDIs) has evolved, primarily designed to assist disulfide bonding but eventually devoted to promote protein folding and minimize protein misfolding, aggregation, and cell toxicity (Figure 2).

Figure 2

Schematic representation of the role of disulfide bonds (S-S) and disulfide bonding enzymes (PDIs) in the misfolding and aggregation of proteins involved in neurodegenerative misfolding diseases. Disulfide bonds stabilize the monomeric protein slowing down the population of aggregation-prone conformations. They also mediate in many cases the formation of aggregates by intermolecular disulfide bonds. PDIs, instead, are upregulated in the presence of protein aggregation as a general response to cellular stress and UPR activation. In some cases PDIs also interact specifically with the aggregating proteins or the aggregates. (Adapted from [1]).

Intramolecular disulfide bonds stabilize the monomeric folding of prion, SOD1, and Tau retarding their aggregation. Intermolecular disulfide bonds, instead, have a more controversial role in pathogenesis. In many cases their presence is still under debate, although their importance in determining the biophysical and biological features of the formed aggregates and as a possible target for treatment.

Different potential roles of PDIs in neurodegenerative diseases are suggested by experimental findings: (i)the upregulation of PDIs in animal models of NMD and in postmortem tissues from NMD patients can be part of the general UPR response to the ER stress driven by extensive protein misfolding in the cell; (ii)the colocalization of PDIs with protein aggregates suggests a chaperone activity of PDIs aimed at limiting protein aggregation itself. If this chaperone activity acts in stabilizing monomers or also in disrupting aggregates has not been addressed so far;(iii)the physical interaction of PDIs with the monomeric forms of several aggregating proteins indicates a role in modulation of the aggregation of specific disease-associated proteins by a direct association.

PDIs appear as a cellular strategy to avoid protein aggregation, but several questions remain unanswered. Which are the mechanisms of PDIs actions in affecting protein aggregation? And what about their effect on protein aggregates? Are different PDIs members specific for different substrates? Interestingly, some observations indeed indicate that some disease and protein specificity of PDI protection is likely to exist. PDI action, in fact, is not specific for amyloid-like aggregates: PDI overexpression inhibits the formation of Ig aggregation in a model of Russell Bodies formation [59] but does not decrease the number of inclusions formed by the variant of α1-antitrypsin [60].

Given the urgent need for novel therapies to treat neurodegenerative misfolding diseases, a solid understanding of disulfide bonding role in protein misfolding and aggregation could lead to the identification of new potential therapeutic targets.

Acknowledgments

Maria Francesca Mossuto was supported by a FEBS Long-Term Fellowship.

References

C. Soto, “Unfolding the role of protein misfolding in neurodegenerative diseases,” Nature Reviews Neuroscience, vol. 4, no. 1, pp. 49–60, 2003.
View at: Publisher Site | Google Scholar
F. Chiti, M. Stefani, N. Taddel, G. Ramponi, and C. M. Dobson, “Rationalization of the effects of mutations on peptide and protein aggregation rates,” Nature, vol. 424, no. 6950, pp. 805–808, 2003.
View at: Publisher Site | Google Scholar
G. G. Tartaglia and M. Vendruscolo, “The Zyggregator method for predicting protein aggregation propensities,” Chemical Society Reviews, vol. 37, no. 7, pp. 1395–1401, 2008.
View at: Publisher Site | Google Scholar
D. Fass, “Disulfide bonding in protein biophysics,” Annual Review of Biophysics, vol. 41, pp. 63–79, 2012.
View at: Google Scholar
C. I. Andreu, U. Woehlbier, M. Torres, and C. Hetz, “Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications,” FEBS Letters, vol. 586, no. 18, pp. 2826–2834, 2012.
View at: Google Scholar
A. M. Benham, “The protein disulfide isomerase family: key players in health and disease,” Antioxidants and Redox Signaling, vol. 16, no. 8, pp. 781–789, 2012.
View at: Publisher Site | Google Scholar
M. F. Mossuto, B. Bolognesi, B. Guixer et al., “Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein,” Angewandte Chemie, vol. 50, no. 31, pp. 7048–7051, 2011.
View at: Publisher Site | Google Scholar
E. Rousseau, B. Dehay, L. Ben-Haïem, Y. Trottier, M. Morange, and A. Bertolotti, “Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 26, pp. 9648–9653, 2004.
View at: Publisher Site | Google Scholar
E. Monsellier and F. Chiti, “Prevention of amyloid-like aggregation as a driving force of protein evolution,” EMBO Reports, vol. 8, no. 8, pp. 737–742, 2007.
View at: Publisher Site | Google Scholar
D. Hamada, T. Tanaka, G. G. Tartaglia et al., “Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin,” Journal of Molecular Biology, vol. 386, no. 3, pp. 878–890, 2009.
View at: Publisher Site | Google Scholar
S. S. Cho, Y. Levy, J. N. Onuchic, and P. G. Wolynes, “Overcoming residual frustration in domain-swapping: the roles of disulfide bonds in dimerization and aggregation,” Physical Biology, vol. 2, supplement 2, pp. S44–S55, 2005.
View at: Publisher Site | Google Scholar
S. Pechmann, E. D. Levy, G. G. Tartaglia, and M. Vendruscolo, “Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 25, pp. 10159–10164, 2009.
View at: Publisher Site | Google Scholar
R. Zahn, A. Liu, T. Lührs et al., “NMR solution structure of the human prion protein,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 1, pp. 145–150, 2000.
View at: Publisher Site | Google Scholar
M. Horiuchi and B. Caughey, “Prion protein interconversions and the transmissible spongiform encephalopathies,” Structure, vol. 7, no. 10, pp. R231–R240, 1999.
View at: Publisher Site | Google Scholar
N. R. Maiti and W. K. Surewicz, “The role of disulfide bridge in the folding and stability of the recombinant human prion protein,” The Journal of Biological Chemistry, vol. 276, no. 4, pp. 2427–2431, 2001.
View at: Publisher Site | Google Scholar
E. Welker, W. J. Wedemeyer, and H. A. Scheraga, “A role for intermolecular disulfide bonds in prion diseases?” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 8, pp. 4334–4336, 2001.
View at: Publisher Site | Google Scholar
N. J. Cobb and W. K. Surewicz, “Prion diseases and their biochemical mechanisms,” Biochemistry, vol. 48, no. 12, pp. 2574–2585, 2009.
View at: Publisher Site | Google Scholar
P. Pasinelli and R. H. Brown, “Molecular biology of amyotrophic lateral sclerosis: insights from genetics,” Nature Reviews Neuroscience, vol. 7, no. 9, pp. 710–723, 2006.
View at: Publisher Site | Google Scholar
D. R. Rosen, T. Siddique, D. Patterson et al., “Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis,” Nature, vol. 362, no. 6415, pp. 59–62, 1993.
View at: Publisher Site | Google Scholar
H. E. Parge, R. A. Hallewell, and J. A. Tainer, “Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 13, pp. 6109–6113, 1992.
View at: Publisher Site | Google Scholar
A. Tiwari and L. J. Hayward, “Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction,” The Journal of Biological Chemistry, vol. 278, no. 8, pp. 5984–5992, 2003.
View at: Publisher Site | Google Scholar
Y. Furukawa and T. V. O'Halloran, “Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation,” The Journal of Biological Chemistry, vol. 280, no. 17, pp. 17266–17274, 2005.
View at: Publisher Site | Google Scholar
C. Kayatekin, J. A. Zitzewitz, and C. R. Matthews, “Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species,” Journal of Molecular Biology, vol. 398, no. 2, pp. 320–331, 2010.
View at: Publisher Site | Google Scholar
H. Deng, Y. Shi, Y. Furukawa et al., “Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 18, pp. 7142–7147, 2006.
View at: Publisher Site | Google Scholar
Y. Furukawa, R. Fu, H. Deng, T. Siddique, and T. V. O'Halloran, “Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 18, pp. 7148–7153, 2006.
View at: Publisher Site | Google Scholar
B. L. Roberts, K. Patel, H. H. Brown, and D. R. Borchelt, “Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures,” PloS ONE, vol. 7, no. 10, Article ID e47838, 2012.
View at: Google Scholar
K. Toichi, K. Yamanaka, and Y. Furukawa, “Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis,” The Journal of Biological Chemistry, vol. 288, no. 7, pp. 4970–4980, 2013.
View at: Google Scholar
A. Andreadis, “Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases,” Biochimica et Biophysica Acta, vol. 1739, no. 2-3, pp. 91–103, 2005.
View at: Publisher Site | Google Scholar
S. Barghorn and E. Mandelkow, “Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments,” Biochemistry, vol. 41, no. 50, pp. 14885–14896, 2002.
View at: Publisher Site | Google Scholar
Y. Furukawa, K. Kaneko, and N. Nukina, “Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties,” The Journal of Biological Chemistry, vol. 286, no. 31, pp. 27236–27246, 2011.
View at: Publisher Site | Google Scholar
T. Härd, “Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies,” FEBS Journal, vol. 278, no. 20, pp. 3884–3892, 2011.
View at: Publisher Site | Google Scholar
J. Riemer, N. Bulleid, and J. M. Herrmann, “Disulfide formation in the ER and mitochondria: two solutions to a common process,” Science, vol. 324, no. 5932, pp. 1284–1287, 2009.
View at: Publisher Site | Google Scholar
O. B. Oka and N. J. Bulleid, “Forming disulfides in the endoplasmic reticulum,” Biochimica et Biophysica Acta, 2013.
View at: Publisher Site | Google Scholar
F. Hatahet and L. W. Ruddock, “Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation,” Antioxidants and Redox Signaling, vol. 11, no. 11, pp. 2807–2850, 2009.
View at: Publisher Site | Google Scholar
M. Schröder and R. J. Kaufman, “ER stress and the unfolded protein response,” Mutation Research, vol. 569, no. 1-2, pp. 29–63, 2005.
View at: Publisher Site | Google Scholar
M. Basso, G. Samengo, G. Nardo et al., “Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis,” PLoS ONE, vol. 4, no. 12, Article ID e8130, 2009.
View at: Publisher Site | Google Scholar
R. R. Erickson, L. M. Dunning, D. A. Olson et al., “In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind β-amyloid,” Biochemical and Biophysical Research Communications, vol. 332, no. 1, pp. 50–57, 2005.
View at: Publisher Site | Google Scholar
C. Hetz, M. Russelakis-Carneiro, S. Wälchli et al., “The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity,” Journal of Neuroscience, vol. 25, no. 11, pp. 2793–2802, 2005.
View at: Publisher Site | Google Scholar
J. C. Watts, H. Huo, Y. Bai et al., “Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones,” PLoS Pathogens, vol. 5, no. 10, Article ID e1000608, 2009.
View at: Google Scholar
A. K. Walker and J. D. Atkin, “Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis,” Neurology Research International, vol. 2011, Article ID 317340, 7 pages, 2011.
View at: Publisher Site | Google Scholar
B. C. Yoo, K. Krapfenbauer, N. Cairns, G. Belay, M. Bajo, and G. Lubec, “Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease,” Neuroscience Letters, vol. 334, no. 3, pp. 196–200, 2002.
View at: Publisher Site | Google Scholar
C. Hetz, M. Russelakis-Carneiro, K. Maundrell, J. Castilla, and C. Soto, “Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein,” The EMBO Journal, vol. 22, no. 20, pp. 5435–5445, 2003.
View at: Publisher Site | Google Scholar
C. A. Hetz and C. Soto, “Stressing out the ER: a role of the unfolded protein response in prion-related disorders,” Current Molecular Medicine, vol. 6, no. 1, pp. 37–43, 2006.
View at: Publisher Site | Google Scholar
J. D. Atkin, M. A. Farg, B. J. Turner et al., “Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1,” The Journal of Biological Chemistry, vol. 281, no. 40, pp. 30152–30165, 2006.
View at: Publisher Site | Google Scholar
J. D. Atkin, M. A. Farg, A. K. Walker, C. McLean, D. Tomas, and M. K. Horne, “Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis,” Neurobiology of Disease, vol. 30, no. 3, pp. 400–407, 2008.
View at: Publisher Site | Google Scholar
C. Hetz, P. Thielen, S. Matus et al., “XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy,” Genes and Development, vol. 23, no. 19, pp. 2294–2306, 2009.
View at: Publisher Site | Google Scholar
Y. Honjo, S. Kaneko, H. Ito et al., “Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis,” Amyotrophic Lateral Sclerosis, vol. 12, no. 6, pp. 444–450, 2011.
View at: Publisher Site | Google Scholar
A. K. Walker, M. A. Farg, C. R. Bye, C. A. McLean, M. K. Horne, and J. D. Atkin, “Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis,” Brain, vol. 133, part 1, pp. 105–116, 2010.
View at: Publisher Site | Google Scholar
M. A. Farg, K. Y. Soo, A. K. Walker et al., “Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase,” Neurobiology of Aging, vol. 33, no. 12, pp. 2855–2868, 2012.
View at: Publisher Site | Google Scholar
T. Uehara, T. Nakamura, D. Yao et al., “S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration,” Nature, vol. 441, no. 7092, pp. 513–517, 2006.
View at: Publisher Site | Google Scholar
F. Casoni, M. Basso, T. Massignan et al., “Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis,” The Journal of Biological Chemistry, vol. 280, no. 16, pp. 16295–16304, 2005.
View at: Publisher Site | Google Scholar
W. A. Holtz and K. L. O'Malley, “Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons,” The Journal of Biological Chemistry, vol. 278, no. 21, pp. 19367–19377, 2003.
View at: Publisher Site | Google Scholar
E. J. Ryu, H. P. Harding, J. M. Angelastro, O. V. Vitolo, D. Ron, and L. A. Greene, “Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease,” Journal of Neuroscience, vol. 22, no. 24, pp. 10690–10698, 2002.
View at: Google Scholar
K. J. Conn, W. Gao, A. McKee et al., “Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology,” Brain Research, vol. 1022, no. 1-2, pp. 164–172, 2004.
View at: Publisher Site | Google Scholar
E. Colla, P. Coune, Y. Liu et al., “Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo,” Journal of Neuroscience, vol. 32, no. 10, pp. 3306–3320, 2012.
View at: Publisher Site | Google Scholar
H. Cheng, L. Wang, and C. Wang, “Domain a of protein disulfide isomerase plays key role in inhibiting α-synuclein fibril formation,” Cell Stress and Chaperones, vol. 15, no. 4, pp. 415–421, 2010.
View at: Publisher Site | Google Scholar
Y. Honjo, H. Ito, T. Horibe et al., “Derlin-1-immunopositive inclusions in patients with Alzheimer's disease,” Neuroreport, vol. 23, no. 10, pp. 611–615, 2012.
View at: Google Scholar
Y. Honjo, H. Ito, T. Horibe, R. Takahashi, and K. Kawakami, “Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease,” Brain Research, vol. 1349, pp. 90–96, 2010.
View at: Publisher Site | Google Scholar
R. Ronzoni, T. Anelli, M. Brunati, M. Cortini, C. Fagioli, and R. Sitia, “Pathogenesis of ER storage disorders: modulating russell body biogenesis by altering proximal and distal quality control,” Traffic, vol. 11, no. 7, pp. 947–957, 2010.
View at: Publisher Site | Google Scholar
S. Granell, G. Baldini, S. Mohammad et al., “Sequestration of mutated α1-antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function,” Molecular Biology of the Cell, vol. 19, no. 2, pp. 572–586, 2008.
View at: Publisher Site | Google Scholar

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Copyright © 2013 Maria Francesca Mossuto. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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