Table of Contents Author Guidelines Submit a Manuscript
International Journal of Cell Biology
Volume 2013, Article ID 560421, 18 pages
http://dx.doi.org/10.1155/2013/560421
Research Article

Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

1Departments of Neurology, MC2030, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA
2Departments of Neurobiology, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA

Received 12 May 2013; Accepted 20 September 2013

Academic Editor: Roberto Chiesa

Copyright © 2013 Constanza J. Cortes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [16 citations]

The following is the list of published articles that have cited the current article.

  • Yoshiyuki Suzuki, “Emerging novel concept of chaperone therapies for protein misfolding diseases,” Proceedings of The Japan Academy Series B-Physical and Biological Sciences, vol. 90, no. 5, pp. 145–162, 2014. View at Publisher · View at Google Scholar
  • Mohadeseh Mehrabian, Dylan Brethour, Sarah MacIsaac, Jin Kyu Kim, C Geeth Gunawardana, Hansen Wang, and Gerold Schmitt-Ulms, “CRISPR-Cas9-based knockout of the prion protein and its effect on the proteome.,” PloS one, vol. 9, no. 12, 2014. View at Publisher · View at Google Scholar
  • Daisuke Ishibashi, Takujiro Homma, Takehiro Nakagaki, Takayuki Fuse, Kazunori Sano, Hanae Takatsuki, Ryuichiro Atarashi, and Noriyuki Nishida, “Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells,” Plos One, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
  • Viviana A. Cavieres, Alexis Gonzalez, Vanessa C. Munoz, Claudia P. Yefi, Hianara A. Bustamante, Rafael R. Barraza, Cheril Tapia-Rojas, Carola Otth, Maria Jose Barrera, Carlos Gonzalez, Gonzalo A. Mardones, Nibaldo C. Inestrosa, and Patricia V. Burgos, “Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy,” Plos One, vol. 10, no. 8, 2015. View at Publisher · View at Google Scholar
  • Tomáš Olejár, Radoslav Matěj, Zdeněk Rohan, and Karel Holada, “The contribution of proteinase-activated receptors to intracellular signaling, transcellular transport and autophagy in Alzheimer's disease,” Current Alzheimer Research, vol. 12, no. 1, pp. 2–12, 2015. View at Publisher · View at Google Scholar
  • M.A. Hayat, “Overview of Autophagy,” Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, pp. 1–71, 2016. View at Publisher · View at Google Scholar
  • M.A. Hayat, “Overview of Autophagy,” Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, pp. 3–84, 2016. View at Publisher · View at Google Scholar
  • Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, and Lifeng Yang, “Role of the AMPK Pathway in Promoting Autophagic Flux via Modulating Mitochondrial Dynamics in Neurodegenerative Diseases: Insight into Prion Diseases,” Ageing Research Reviews, 2017. View at Publisher · View at Google Scholar
  • Priyanka Majumder, and Oishee Chakrabarti, “Lysosomal Quality Control in Prion Diseases,” Molecular Neurobiology, 2017. View at Publisher · View at Google Scholar
  • M.A. Hayat, “Overview of Autophagy,” Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, pp. 3–90, 2017. View at Publisher · View at Google Scholar
  • M.A. Hayat, “Overview of Autophagy,” Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, pp. 1–122, 2017. View at Publisher · View at Google Scholar
  • Frank F. Heisler, Yvonne Pechmann, Ines Wieser, Hermann C. Altmeppen, Leonhard Veenendaal, Mary Muhia, Michaela Schweizer, Markus Glatzel, Susanne Krasemann, and Matthias Kneussel, “Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression,” Neuron, 2018. View at Publisher · View at Google Scholar
  • Jiapu Zhang, and Jiapu Zhang, “Potential Antiprion Drugs,” Molecular Dynamics Analyses of Prion Protein Structures, vol. 10, pp. 297–303, 2018. View at Publisher · View at Google Scholar
  • Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Naveed Sabir, and Lifeng Yang, “Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases With Focus on Prion Diseases,” Frontiers in Aging Neuroscience, vol. 10, 2018. View at Publisher · View at Google Scholar
  • Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Naveed Sabir, Mazhar Hussain Mangi, and Lifeng Yang, “p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases,” Frontiers in Molecular Neuroscience, vol. 11, 2018. View at Publisher · View at Google Scholar
  • Stefano Thellung, Alessandro Corsaro, Mario Nizzari, Federica Barbieri, and Tullio Florio, “Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity,” International Journal of Molecular Sciences, vol. 20, no. 4, pp. 901, 2019. View at Publisher · View at Google Scholar