C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer

Table 1

CtBP interacting protein complexes.

Factor	Function	Ref
Zfh-1	Transcription repression	[29]
Hairy	Transcription repression	[30]
Knirps	Transcription repression	[31]
Giant	Transcription repression	[32]
Kruppel	Transcription repression	[32]
Snail	Transcription repression	[32]
ZEB1/2	Transcription repression	[33]
CtIP	Genome stability	[34]
BRCA1	Transcription repression	[35]
NET (ELK4)	Transcription repression	[36]
KLF8 (ZNF741)	Transcription repression	[37, 38]
Evi-1	Inducing blocks to differentiation	[39]
HDAC 4, 5, 7	Histone deacetylation	[40]
HDAC 1, 2, 3	Histone deacetylation	[41, 42]
G9a	Histone methyltransferase	[42]
EHMT1	Histone methyltransferase	[43]
WIZ	Transcription repression	[44]
Lsd1	Histone demethylase	[42]
ArpNα	Transcription repression	[45]
CoRest (RCOR1)	Transcription repression	[42]
CDYL	Transcription repression	[46]
CBX4	Transcription repression	[46]
P300	HAT inhibition	[47]
BCOR-L1	Transcription repression	[48]
RIP140	Hormone regulation	[49]
FOG	Transcription repression	[50]
PRDM16	Transcription repression	[51]
Hmd2	Transcription repression	[52]
HIC1	Regulate SIRT expression	[53, 54]
ZNF366	Estrogen control gene regulation	[55]
BCL3	Transcription repression	[56]
BCL6	Autoregulation of transcription	[56]
Ikaros	Transcription repression	[57]
Sin3A	Transcription repression	[57]
TCF4	Transcription repression	[58]
BKLF (KLF3)	Stability of subcellular localization	[59]
Pnn	Transcription Repression	[60]
APC	Degradation	[61–64]
ARF	Degradation	[65]
HIPK2	Ubiquitination, proteasomal degradation	[66]
JNK1	Phosphorylation	[67]
TBL1	Dephosphorylation	[67]
CDK7/CCNH	Post-translational stability	[68]
Huntingtin	Unknown	[69]
Glis2	Transcriptional repression	[70]
PLD1	Activation of macropinocytosis	[71]
Smad6	Transcriptional repression	[60]
Ataxin	CtBP antagonism
PARP1	Corepressor complex	[72]
Sox6	Transcriptional repression	[73]
Spen	Transcriptional repression	[74]
BCoRL1	BCL6 transcriptional	[47]
	Co-repression
Eos (IKaros family member)	Transcriptional repression	[75]
Acetylcholinesterase-S (AChE-S)	Antagonize CtBP transcriptional repression	[76]
SatB1	Co-repressor complex	[77]
nNos	Cytoplasmic localization	[78]
Tel/EVT6	Control of endothelial sprouting	[79]
ER-beta	Suppression of inflammatory response in CNS microglia and astrocytes	[80]
KLF12	Transcriptional repression	[81]
MLL	Transcriptional repression	[82]
HDGF	Transcriptional repression	[83]
KCNIP3/KCHIP	Calcium-dependent Transcriptional repression	[84]
MITR	Transcriptional repression	[40]