C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer

Table 2

CtBP regulators

Protein	Mode of regulation	Ref.
APC	Protein degradation	[61–63, 85]
	Proteasome dependent
HIPK2	Phosphorylation-dependent	[86, 87]
	Protein degradation
TBL1	Protein degradation	[88]
	Proteasome-dependent
Ink4a/Arf	Protein degradation	[89, 90]
	Proteasome mediated	[64]
BCL3	Protein Stabilization	[91]
PKA	CtBP dimerization	[92]
AMPK1	Phosphorylation dependent inactivation	[93]
XIAP	Polyubiquitination degradation	[94]
Stub1/CHIP	CtBP2 polyubiquitination degradation	[95]
AKT1	Phosphorylation induced decreased dimerization	[96]
JNK1	Phosphorylation dependent	[66]
	Proteasomal degradation
PAK1	Phosphorylation dependent	[97]
	Translocation to the cytoplasm
CBX4/UBC9	Sumoylation-dependent nuclear retention	[98–101]
p300	Acetylation increased nuclear retention	[102]