Traffic Control of Bacteria-Derived Molecules: A New System of Host-Bacterial Crosstalk

Figure 2

Bacteria-derived CSF and poly P are transported through different trafficking systems and exhibit cytoprotective and anti-inflammatory effects in human intestinal tissues. Bacillus subtilis secrets CSF, which is transported by epithelia cell membrane transporter OCTN2 (a). Lactobacillus brevis secrets poly P, which is captured by integrin β1 and absorbed by caveolin-dependent endocytosis (b). These trafficking systems mediate the augmentation of the intestinal barrier function and exhibit anti-inflammatory effects.