From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases

Table 1

Prion model of induction described for neurodegenerative diseases.

Disease	Normally folded protein; “Precursor”	Abnormally folded protein; “Prion form”	Protein aggregates detected	Seeding inoculum	Prion-like propagation in mammals	References
CJD/scrapie	PrP^C	PrP^Sc	PrP^Sc deposits plaques	Various mammalian prions and recPrP fibrils	WT and Tg mice; Non-human primates	[32, 33, 37–40]; [45–50]
Alzheimer (AD)	Amyloid precursor protein (APP)	Amyloid beta peptides A𝛽	Aβ plaques	Human AD and Tg mice brain extracts; blood	Marmosets; TgAPP2576; TgAPP23, TgAPP/PS1	[53–58]
Tauopathies	Tau	Tau aggregates	Neurofibrillary tangles (NFTs)	Tg(HuTauP301S) brain extracts	Tg(wt Tau)	[59, 60]
Parkinson (PD)	α-Synuclein	α-Synuclein aggregates	Lewy bodies	Human; preformed; α-Syn fibrils	(i) Fetal tissue grafts in human PD patients	[61, 62]
					(ii) Tg (α-SynA53T) and WT mice	[63, 64]