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International Journal of Cell Biology
Volume 2014 (2014), Article ID 490275, 6 pages
Review Article

Necroptosis: Molecular Signalling and Translational Implications

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy

Received 10 October 2013; Revised 11 December 2013; Accepted 16 December 2013; Published 23 January 2014

Academic Editor: Alessio Paone

Copyright © 2014 Claudia Giampietri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.