Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery

Figure 9

Efficacy study of nCaCDDP conducted on J:Nu mice bearing BT-47 tumors. Animals were treated once when their tumor volume reached  mm³ and were compared to 2.8 mg/kg CDDP administered near the tumor. Tumor volume, grooming, and weight loss were monitored every other day following treatment. (a) The graph depicts average tumor volume (mm³) per group versus days posttreatment. The negative control saline IT (70 L) had no effect on tumor growth. nCa (60 L) had no effect on tumor growth. CDDP at 2.8 mg/kg administered near the tumor delayed tumor growth. (b) Tumor weight at the end of the study or at time of euthanasia for the efficacy study shown in (a). Tumors were resected and weighed. Animals were euthanized if tumor diameter was measured > 2 cm or at the completion of the study (day 30). No significant differences were found between groups.

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