Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery

Table 1

Average physical characteristics of nCaP^CMHACDDP. Ratio of components, precipitation volume, and stabilizer final concentration remained the same from batch to batch. Yield, CDDP concentration, drug loading, particle size, polydispersity, and zeta potential represent averages and standard deviations from a minimum of three batches.

Physical characteristic	nCaP^CMHACDDP
Ca : P : Stabilizer (v : v : v)	2 : 2 : 1
Total precipitation volume (mL)	250
Stabilizer final concentration (mg/mL)	4
Yield (mg nCaP/mL precipitation)	2.3 ± 0.4
CDDP concentration (mg/mL)	4.1 ± 1.4
Drug loading (g CDDP/mg nCaP)	140 ± 12
Particle size (nm)	204 ± 13 nm
Polydispersity	0.116
Zeta potential (mV)	−43 ± 4