Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery

Table 2

Tabulated IC50 values of CDDP, Aq CDDP, Aq CDDP-CMHA, and nCaP^CMHACDDP examined with BT-474 and BT-474_EMT cells, from curves shown in Figures 7(a) and 7(b), respectively. For BT-474 cells Aq CDDP and nCaP^CMHACDDP were both significantly more effective than CDDP alone and Aq CDDP-CMHA was significantly less effective than CDDP. For BT-474_EMT cells nCaP^CMHACDDP was as cytotoxic as CDDP alone and Aq CDDP was significantly more effective while Aq CDDP-CMHA was significantly less effective.

Cell type	IC50 (g/mL)
	CDDP	Aq CDDP	Aq CDDP-CMHA	nCaP^CMHACDDP
BT-474	50.6 ± 3.3	17.1 ± 0.9^c	59.0 ± 2.7^c	23.1 ± 3.9^c
BT-474EMT	10.5 ± 1.1	8.78 ± 0.6^a	16.24 ± 1.5^c	12.1 ± 1.4

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^c.