Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics

Figure 1

General organization of the metabolic networks in cancer cells. The input layer’s internal (oncogenic signals) and external (nutrients in the environment) signals influence the organization of metabolic pathways and thereby regulate the output layer (see text for details). The general impact of the main oncogenic signals (PI3K/Akt and MAPK pathways) on the metabolic organization of cancer cells is illustrated.