Hyperglycemia-Induced Changes in Hyaluronan Contribute to Impaired Skin Wound Healing in Diabetes: Review and Perspective

Figure 1

Skin biopsies from a wound edge at 24 h after wounding. Specimens from (a) normal mice (wild type) or (b) knockout mice lacking the genes for HAS1 and HAS3 (Has1/3 null) were stained with an HA binding probe to visualize HA (green) and an anti-myeloperoxidase antibody to visualize neutrophils (red). Note the marked loss of HA and increase in neutrophils extravasating from the blood vessel (BV) in the HAS1/3 deficient skin. Bar, 50 μm. From [50], used with permission.

(a)

(b)