Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Figure 5

Histological colitis scores for DSS-treated mice. Hematoxylin and eosin stained rectal cross-sections from DSS-treated mice were scored for pathology changes including erosion of the epithelium layer, leukocyte infiltration, submucosal swelling, muscularis mucosae hyperplasia, and increased vascularization as described in methods. (a) Bars represent the average scores of groups of mice of the same genotype at the indicated time points with error bars reflecting ±SEM. Comparison of null mice to wild-type mice at the indicated time point: , , and at 95% confidence. (b) The colitis score at day 7 is presented with significance of HAS3 null compared to wild-type mice at 95% confidence noted .

(a)

(b)