Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

Figure 7

Effects of anti-miR-10b on cisplatin-induced cell growth inhibition in cells following 200 kDa-HA treatment. Effects of cisplatin-induced cell growth inhibition in cells transfected with negative miRNA control plus 200 kDa-HA addition (a) or with no HA addition (b) or transfected with anti-miR-10b inhibitor plus 200 kDa HA addition (c) or with no HA addition (d) for 7 days. Tumor cell growth inhibition (IC₅₀) is designated as “the μM concentration of chemotherapeutic drug (e.g., cisplatin treatment) that causes 50% inhibition of tumor cell growth” using CellTiter-Glo Luminescent Cell Viability Assay as described in the Section 2. IC₅₀ values are presented as the means ± standard deviation.