Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells

Figure 5

SAHA, MS275, and MC1568 prevent cortisol and IL1β-induced decreases in 11β-HSD2 expression. Graphical representation and 11β-HSD2 expression in JEG-3 cells treated with 2 μM Cort or 10 ng/ml IL-1β in the presence or absence of 10 μM SAHA (a, d), MS275 (b, e), or MC1568 (c, f) for 24 h. Data are expressed as mean ± SEM. ( compared to DMSO; one-way ANOVA with post hoc Tukey’s test; 25 cells per group per experiment; .)

(a)

(b)

(c)

(d)

(e)

(f)