Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro

Table 5

qRT-PCR results of comparison among OS-induced control, OS+Xav939-, and OS+Xav939+rhAsp-treated AVICs.

		OS+Xav939-conditioned AVICs	OS+Xav939+rhAsp-conditioned AVICs
Negative regulatory molecule of bone cell differentiation	Asporin	Unchanged	Upregulated
Osteogenic marker genes	Osteopontin, Runx2	Unchanged	Downregulated
Wnt signaling-specific markers genes	β-Catenin	Downregulated	Downregulated
	Wnt3a	Downregulated	Downregulated
	Dkk1	Upregulated	Upregulated