the nuclear envelop protein nesprin have been primarili studi dure interphas where function maintain nuclear shape size posit analyz here function nesprin2 chromatin interact interphas divid cell character region rod domain nesprin2 predict smc domain 14361766 show domain can interact itself furthermor has capac bind smc2 smc4 core subunit condensin the interact observ dure all phase cell cycl particular strong dure phase persist also dure mitosi nesprin2 knockdown did affect condensin distribut howev notic signific higher number chromatin bridg nesprin2 knockdown cell anaphas thus nesprin2 may have impact chromosom which might due it interact condensin indirect mechan provid it interact nuclear envelop

Xin Xing

Carmen Mroß

Linlin Hao

Martina Munck

Alexandra Herzog

Clara Mohr

C. P. Unnikannan

Pranav Kelkar

Angelika A. Noegel

Ludwig Eichinger

Sascha Neumann

Nesprin-2 Interacts with Condensin Component SMC2

the serin proteas thrombin activ proteaseactiv receptor pars famili gproteincoupl receptor gpcrs activ proteolyt cleavag extracellular ntermin domain four member famili have been identifi par14 the activ proteaseactiv receptor 1 par1 prototyp receptor famili lead increas intracellular 2 concentr 2 mediat coupl phospholipas plc activ have previous shown stimul par1 thrombin promot intracellular signal lead rpe cell transform prolifer migrat which character fibroprolif eye diseas lead blind within context elucid mechan involv par1 inactiv utmost import due irrevers natur par1 activ it inactiv must effici regul order termin signal using arpe19 human rpe cell line character thrombininduc 2 increas demonstr calciumdepend activ calpain mediat par1 calpain famili calciumactiv cystein proteas involv multipl cellular process includ intern membran protein through clathrinco vesicl demonstr par1induc calpain activ result degrad spectrin calpain essenti receptor endocytosi consequ decreas par1 membran express collect present result identifi novel calpaindepend mechan par1 inactiv follow exposur thrombin

Alejandro Alvarez-Arce

Irene Lee-Rivera

Edith López

Arturo Hernández-Cruz

Ana María López-Colomé

Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization

has been report water interfac hydrophil thin film form exclus zone which has higher densiti than ordinari water similar phenomenon observ hydrat hydrophil ceram powder water turn threedimension celllik structur compos high densiti water low densiti water this structur water appear have stimul effect plant growth this report outlin our studi antioxid properti structur water it effect cell bioactiv cultur media which were prepar util antioxid structur water promot viabil raw 2647 macrophag cell three time the same tendenc observ other cell includ iec6 c2c12 3t3l1 also cytokin express splenocyt taken from mous spleen increas same manner the water also appear suppress viabil cancer cell mcf7 these result strong suggest structur water help activ normal cell while suppress those malign cell

Seong Gu Hwang

Ho-Sung Lee

Byung-Cheon Lee

GunWoong Bahng

Effect of Antioxidant Water on the Bioactivities of Cells

tissu regener repair have receiv much attent medic field over year the studi amphibian newt salamand has uncov mani process occur anim dure fulllimb digit regener process high limit mammal understand process amphibian could shed light how develop improv process mammal amputat injuri mammal usual result format scar tissu limit regrowth limb digit howev has been observ veri tip digit finger toe can partial regrow human mice under certain condit this review summar compar process involv salamand limb regener mammalian wound heal digit regener mice human

Yohan Choi

Fanwei Meng

Charles S. Cox

Kevin P. Lally

Johnny Huard

Yong Li

Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals

the thrombopoietin tpo gene express human ovari cancer cell from patient ovarian carcinomatosi well sever cancer cell line includ mdamb231 breast cancer k562 hl60 leukem cell ovcar3nih skov3 ovarian cancer perform use pcr realtim pcr gene sequenc human liver tissu use control the presenc tpo cell it regul activ protein were explor flow cytometri tpo content cell extract well plasma patient ovarian cancer evalu elisa the function tpo perform cocultur basi viabil tpodepend cell line mtt assay annexinv label liver ovarian tissu all cancer cell line except mdamb231 express three tpo1 full length tpo tpo2 12 delet tpo3 116 delet variant primari ovarian cancer cell well cancer cell line produc tpo the thrombopoietin product ovcar3 increas when cell stimul apc ovcar3 cell supernat can replac exogen tpo inhibit tpodepend cell line apoptosi the thrombopoietin produc tumor may have direct effect thrombocytosi thrombosi occurr patient ovarian cancer

Samaher Besbes

Shahid Shah

Iman Al-dybiat

Shahsoltan Mirshahi

Helene Helfer

Haythem Najah

Caroline Fourgeaud

Marc Pocard

Ibtissem Ghedira

Jeannette Soria

Massoud Mirshahi

Thrombopoietin Secretion by Human Ovarian Cancer Cells

exposur matern cortisol play crucial role fetal organogenesi howev fetal overexposur cortisol has been link rang short longterm advers outcom normal prevent express enzym placenta call 11beta hydroxysteroid dehydrogenas type 2 11 hsd2 which convert activ cortisol it inact metabolit cortison placent 11 hsd2 known reduc number advers pregnanc complic possibl through epigenet mechan result number panhdac inhibitor have been examin abil promot 11 hsd2 express howev known effect panhdac inhibit general phenomenon effect depend upon specif class hdacs here examin abil pan classspecif hdac inhibitor regul 11 hsd2 express jeg3 cell find pan class class iia hdac inhibit promot 11 hsd2 express prevent cortisol interleukin1 induc decreas it express these result demonstr target specif class hdacs can promot 11 hsd2 express jeg3 cell this add grow bodi evid suggest hdacs may crucial maintain normal fetal develop

Katie L. Togher

Louise C. Kenny

Gerard W. O’Keeffe

Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells

the class transactiv ciita essenti regul major histocompat class mhc gene transcript master regul mhc transcript ciita regul imper requir various posttransl modif ptms order facilit it role previous identifi various ubiquitin event ciita monoubiquitin import ciita transact while k63 link ubiquitin involv crosstalk erk12 phosphoryl where togeth mediat cellular movement from cytoplasm nuclear region further ciita also modifi degrad k48 polyubiquitin howev ligas respons modif unknown show ciita ubiquitin transact enhanc histon acetyltransferas hat p300 cbp associ factor pcaf ligas region within pcaf necessari both addition pcaf mediat ubiquitin independ pcaf hat domain acetyl defici ciita k48 polyubiquitin degrad presenc pcaf last identifi histon acetyltransferas pcaf ligas respons ciita ubiquitin

Julie E. Morgan

Susanna F. Greer

Pulling a Ligase out of a &#x201c;HAT&#x201d;: pCAF Mediates Ubiquitination of the Class II Transactivator

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