International Journal of Cell Biology

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms


Status
Published

Lead Editor

1University of Oklahoma Health Sciences Center, Oklahoma City, USA

2Cleveland Clinic Lerner Research Institute, Cleveland, USA

3University of Nebraska, Lincoln, USA

4Oregon Health & Science University, Beaverton, USA


Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms

Description

Hyaluronan is an alternating copolymer of glucuronic acid and N-acetylglucosamine that is found in all vertebrate tissues. Depending on the physiologic situation, the size of hyaluronan polymers can vary from 4 sugars to 50,000 sugars. The rapid rate of discovery in hyaluronan biology has revealed the involvement of this glycosaminoglycan in fundamental processes in biology and biomedicine including cancer, regenerative medicine, stem cell survival, and inflammatory diseases. For example, a recent international meeting of hyaluronan researchers from 25 countries highlighted the diversity of normal systems and disease states in which this deceivingly simple polysaccharide plays complicated and critical roles.

We invite all investigators to contribute original research articles or review articles that elucidate and highlight recent progress in understanding the molecular mechanisms underlying the role of hyaluronan in normal physiological processes and in various human diseases. In particular, we are interested in articles that describe the influence and mechanism of action of hyaluronan in cell and organ function, tumor biology and metastasis, regenerative medicine, connective tissue and musculoskeletal biology, aging, inflammation, immunity, neural function, cardiovascular and lymphatic biology, and human diseases.

Potential topics include, but are not limited to:

  • Hyaluronan-mediated processes in lymphatic and vascular tumor metastasis
  • Hyaluronan-mediated processes in tissue tumorigenesis
  • Contributions of hyaluronan to normal and tumor stem cell biology
  • The roles of hyaluronan in inflammation, fibrosis, and neurological diseases
  • Hyaluronan-mediated signaling in normal and pathological processes and diseases
  • The regulation of hyaluronan synthesis, degradation, and turnover
  • The roles of hyaluronan in differentiation and development

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 690572
  • - Editorial

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms

Melanie A. Simpson | Carol de la Motte | ... | Paul H. Weigel
  • Special Issue
  • - Volume 2015
  • - Article ID 834893
  • - Review Article

Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis

Shibnath Ghatak | Edward V. Maytin | ... | Suniti Misra
  • Special Issue
  • - Volume 2015
  • - Article ID 367579
  • - Review Article

Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior

Paul H. Weigel
  • Special Issue
  • - Volume 2015
  • - Article ID 563818
  • - Review Article

Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

Jaime M. Cyphert | Carol S. Trempus | Stavros Garantziotis
  • Special Issue
  • - Volume 2015
  • - Article ID 368584
  • - Review Article

Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases

Larry S. Sherman | Steven Matsumoto | ... | Stephen A. Back
  • Special Issue
  • - Volume 2015
  • - Article ID 745237
  • - Research Article

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Sean P. Kessler | Dana R. Obery | Carol de la Motte
  • Special Issue
  • - Volume 2015
  • - Article ID 614297
  • - Research Article

Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways

Shannon M. Ruppert | Ben A. Falk | ... | Paul L. Bollyky
  • Special Issue
  • - Volume 2015
  • - Article ID 537560
  • - Review Article

Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery

Suniti Misra | Vincent C. Hascall | ... | Shibnath Ghatak
  • Special Issue
  • - Volume 2015
  • - Article ID 701738
  • - Review Article

Hyperglycemia-Induced Changes in Hyaluronan Contribute to Impaired Skin Wound Healing in Diabetes: Review and Perspective

Sajina Shakya | Yan Wang | ... | Edward V. Maytin
  • Special Issue
  • - Volume 2015
  • - Article ID 989070
  • - Research Article

Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

Marisa Shiina | Lilly Y. W. Bourguignon
International Journal of Cell Biology
 Journal metrics
Acceptance rate14%
Submission to final decision14 days
Acceptance to publication156 days
CiteScore4.430
Impact Factor-
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